Puzyński S, Rybakowski J, Kocur J, Rydzyński Z, Beresewicz M, Bogdanowicz E, Duszyk S, Gruszczyński W, Kalinowski A, Koszewska I
II Kliniki Psychiatrycznej, Instytutu Psychiatrii i Neurologii w Warszawie.
Psychiatr Pol. 1994 Sep-Oct;28(5):593-600.
The multicenter trials were performed in a group of 86 depressive inpatients (among them 64 with endogenous depression) managed with fluoxetine (Prozac). It was established that the drug is most effective in managing psychogenic depressions and may also be of use in endogenous depressions, among them in drug resistant ones. Tolerance to the drug was satisfactory, 62% did not show any unwanted side-effects. The rest of the group displayed sleep disorders, increased anxiety, lost of appetite and nausea. Changes in the laboratory parameters and non-specific changes in the electrocardiogram were observed sporadically. Fluoxetine seemed not to have any direct cholinolytic effect.
多中心试验在一组86名使用氟西汀（百忧解）治疗的抑郁症住院患者中进行（其中64例为内源性抑郁症）。结果表明，该药物在治疗心因性抑郁症方面最为有效，在内源性抑郁症（包括耐药性抑郁症）中也可能有用。对该药物的耐受性良好，62%的患者未出现任何不良反应。其余患者出现睡眠障碍、焦虑增加、食欲不振和恶心。偶尔观察到实验室参数变化和心电图非特异性改变。氟西汀似乎没有任何直接的抗胆碱作用。
