Leckman J F, Goodman W K, North W G, Chappell P B, Price L H, Pauls D L, Anderson G M, Riddle M A, McDougle C J, Barr L C
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520.
Psychoneuroendocrinology. 1994;19(8):723-49. doi: 10.1016/0306-4530(94)90021-3.
Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells, which project to widely distributed sites in the CNS as well as the neurohypophysis. Central OT affects a variety of cognitive, grooming, affiliative, sexual, and reproductive behaviors in animals. Obsessive Compulsive Disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship to dimensions of behavior associated with OT. Anecdotal data and a recently completed cerebrospinal fluid (CSF) study provide evidence that some forms of OCD are related to OT dysfunction. Based on these findings, we hypothesize: 1) that some forms of OCD are at the extreme end of a range of normal behaviors that are mediated by OT and related systems; and that 2) some normal cognitive, affiliative, and sexual behaviors contain elements that are similar to features of OCD. Alternative hypotheses are considered, and a series of predictions are presented concerning the relationship between central OT and the onset, course, treatment response, and response to challenge procedures seen in this form of OCD.
催产素（OT）是一种在下丘脑细胞中合成的神经分泌性九肽，其投射至中枢神经系统以及神经垂体中广泛分布的部位。中枢催产素会影响动物的多种认知、梳理、亲和、性行为及生殖行为。强迫症（OCD）包括一系列认知和行为症状，这些症状与催产素相关的行为维度存在一定关联。轶事数据以及最近完成的一项脑脊液（CSF）研究提供了证据，表明某些形式的强迫症与催产素功能障碍有关。基于这些发现，我们提出以下假设：1）某些形式的强迫症处于由催产素及相关系统介导的一系列正常行为的极端情况；以及2）一些正常的认知、亲和及性行为包含与强迫症特征相似的元素。我们考虑了其他假设，并提出了一系列关于中枢催产素与这种形式的强迫症的发病、病程、治疗反应及对激发程序的反应之间关系的预测。
