Chuaqui R, Verni J
Departamento de Anatomía Patológica, Pontificia Universidad Católica de Chile.
Rev Chil Obstet Ginecol. 1993;58(4):304-9.
"Nonclassic" cytologic signs (NCS) of infection by human papillomavirus (HPV) were analyzed in two groups of patients: A: (condylomata) 81 women with both condylomata confirmed by biopsy and a cervical smear not showing the "classic" signs of HPV infection, and B: (controls) 50 cervical smears diagnosed as negative. In group A, 96% showed nuclear hyperchromatism, 78% showed perinuclear halos, 77% showed clear cytoplasm, and 74% showed mild koilocytosis. In 89% of the condylomata cases at least four NCS were found. In the control group only three cases showed nuclear hyperchromatism; the most frequent NCS in this group was perinuclear halo (50%). The frequency in which NCS of condylomata are found in smears without the classic signs is high. Nevertheless, 11% of these showed less than four NCS; in all of them, nuclear hyperchromatism was prominent. This is the most useful NCS in the diagnosis of HPV infection.
对两组患者的人乳头瘤病毒（HPV）感染的“非典型”细胞学特征（NCS）进行了分析：A组：（尖锐湿疣组）81名女性，经活检确诊为尖锐湿疣，宫颈涂片未显示HPV感染的“典型”特征；B组：（对照组）50份诊断为阴性的宫颈涂片。A组中，96%表现为核深染，78%表现为核周晕，77%表现为胞质透亮，74%表现为轻度空泡化。在89%的尖锐湿疣病例中至少发现了四种NCS。对照组仅3例表现为核深染；该组最常见的NCS是核周晕（50%）。在无典型特征的涂片中发现尖锐湿疣NCS的频率很高。然而，其中11%的涂片显示少于四种NCS；在所有这些涂片中，核深染都很突出。这是诊断HPV感染最有用的NCS。
