Cabrera J, Canahuate E, del Campo S L, Poloni O, Ramírez S I
Departamento de Obstetricia y Ginecología, Facultad de Medicina Universidad de Concepción, Hospital Guillermo Grant Benavente.
Rev Chil Obstet Ginecol. 1993;58(4):317-22.
The vaginal response to estriol succinate was studied in 40 oncogynecological patients, 20 with irradiation (study group) and 20 without irradiation (control group). Both groups had artificial established menopause at the beginning of the treatment. The previous clinical and cytological patterns to estrogen therapy were more severe in the irradiated group; they presented the highest degree of vaginal atrophy which was related to the type and therapeutic dose used. Response of the study group to a continuous 4 mg of estriol as well as the control group, both has a positive effect in vaginal cytology and alleviates postmenopausal symptoms and improve the quality of life.
对40例肿瘤妇科患者进行了研究，观察其对琥珀酸雌三醇的阴道反应，其中20例接受过放疗（研究组），20例未接受过放疗（对照组）。两组在治疗开始时均已人工绝经。放疗组之前对雌激素治疗的临床和细胞学表现更为严重；她们表现出最高程度的阴道萎缩，这与所用放疗类型和治疗剂量有关。研究组连续服用4毫克雌三醇以及对照组，对阴道细胞学均有积极作用，可缓解绝经后症状并改善生活质量。
