McCarren M, Goldberg J, Ramakrishnan V, Fabsitz R
Vietnam Era Twin Registry, VA Hospital, Hines, Illinois, 60141-9980.
Sleep. 1994 Aug;17(5):456-61. doi: 10.1093/sleep/17.5.456.
Genetic and environmental influences on insomnia were studied in 2,825 pairs of Vietnam era veteran male twins. The self-reported sleep problems studied included trouble falling asleep, trouble staying asleep, waking often, waking tired and a composite sleep scale. Twin correlations for each of the sleep problems were larger in monozygotic than in dizygotic pairs, with heritability estimates ranging from 0.21 to 0.42. There was no effect of common familial environment. Phenotypic correlations for combat experience and sleep problems were small, ranging from 0.00 to 0.09, with no differences seen in monozygotic and dizygotic twins. When the effects of genes and combat exposure were evaluated simultaneously, there was a significant genetic contribution to all sleep measures, but combat exposure was significantly associated only with overall sleep quality, waking often and having trouble staying asleep.
在2825对越战时期退伍男性双胞胎中研究了遗传和环境对失眠的影响。所研究的自我报告睡眠问题包括入睡困难、难以保持睡眠、经常醒来、醒来时感到疲倦以及一个综合睡眠量表。单卵双胞胎中每种睡眠问题的双胞胎相关性都比双卵双胞胎中的更大，遗传度估计范围为0.21至0.42。不存在共同家庭环境的影响。战斗经历与睡眠问题的表型相关性较小，范围从0.00至0.09，单卵双胞胎和双卵双胞胎中未见差异。当同时评估基因和战斗暴露的影响时，所有睡眠指标都有显著的遗传贡献，但战斗暴露仅与整体睡眠质量、经常醒来和难以保持睡眠显著相关。
