Jirsová Z
Department of Histology and Embryology, 1st Medical Faculty, Charles University, Prague.
Sb Lek. 1993;94(2):125-35.
The chorion of five cases of ampullar pregnancies aged 9-11 weeks was examined in electron microscope. The appearance of chorion is affected by massive haemorrhage into the tubal lumen which occurs in this type of tubal pregnancy and causes its segregation from the tubal wall. The chorionic villi scattered in haematoma show different structure. The electron microscope investigation reveals that many chorionic villi possess the intact microvillous surface and are similar to normal villi of the intrauterine chorion. The development of syncytiotrophoblastic organelles especially as far rough endoplasmic reticulum, Golgi apparatus and mitochondria suggests that the syncytiotrophoblast may for some period be functional under these unfavourable conditions. The chorionic villi imprisoned in blood clot are often covered by fibrin deposits, their syncytium shows considerable folded nuclei with coarse chromatin aggregations, extremely dilated and degranulated endoplasmic reticulum. When syncytium degenerates the fibrinoid sheets invest the isolated portions of the villi. The necrotic villi as well as the cells of cytotrophoblastic islands are embedded in the fibrinoid masses. The cytotrophoblastic cells resembling the cells of basal plate in placenta are found in the tubal wall adjacent to the haematoma.
对5例9 - 11周壶腹部妊娠的绒毛膜进行了电子显微镜检查。绒毛膜的外观受输卵管妊娠时输卵管腔内大量出血的影响，这种出血导致绒毛膜与输卵管壁分离。散在血肿中的绒毛具有不同的结构。电子显微镜研究显示，许多绒毛具有完整的微绒毛表面，与子宫内绒毛膜的正常绒毛相似。合体滋养层细胞器的发育，尤其是粗面内质网、高尔基体和线粒体的发育表明，合体滋养层在这些不利条件下可能在一段时间内仍有功能。被血凝块包裹的绒毛通常被纤维蛋白沉积物覆盖，其合体滋养层显示出相当多折叠的细胞核，伴有粗大的染色质聚集，内质网极度扩张且脱颗粒。当合体滋养层退化时，类纤维蛋白片层包裹着绒毛的孤立部分。坏死的绒毛以及细胞滋养层岛的细胞嵌入类纤维蛋白团块中。在与血肿相邻的输卵管壁中发现了类似于胎盘基底板细胞的细胞滋养层细胞。
