Kaden J, Groth J, May G, Liedvogel B
Department of Laboratory Medicine, Friedrichshain Hospital, Berlin, Germany.
Urol Res. 1994;22(3):131-6. doi: 10.1007/BF00571838.
In a total of 428 urine samples collected from 15 patients aged between 23 and 60 years after cadaveric kidney transplantation during a postoperative hospital stay, Tamm-Horsfall protein (THP) was quantitatively determined using the ELIAS SYNELISA-THP immunoassay. All patients were treated with azathioprine, cyclosporine, prednisolone, given an intraoperative high-dose single antilymphocyte globulin bolus and discharged with functioning grafts. In clinically uncomplicated courses, even after immediate transplant function, the recovery of graft function took on average 7 days. Thereafter the urinary THP excretion was relatively stable and amounted, on average, to 14.5 +/- 4.9 mg/24 h (i.e. was at the lower limit of normal urinary THP excretion). In cases of delayed onset of graft function of undetermined origin accompanied by extremely reduced urinary THP excretion, the functional recovery, whether spontaneous or brought about by treatment, was characterized by a continuous increase in urinary THP excretion. In connection with interstitial rejections urinary THP excretion seems not to be a recommendable diagnostic parameter. Daily measurement of urinary THP is, however, suitable for monitoring the functional state of transplanted kidneys.
在15例年龄在23至60岁之间的患者尸体肾移植术后住院期间收集的总共428份尿液样本中，使用ELIAS SYNELISA - THP免疫测定法定量测定了Tamm - Horsfall蛋白（THP）。所有患者均接受硫唑嘌呤、环孢素、泼尼松龙治疗，术中给予大剂量单次抗淋巴细胞球蛋白推注，出院时移植肾功能良好。在临床过程无并发症的情况下，即使移植肾功能立即恢复，移植肾功能的恢复平均也需要7天。此后，尿THP排泄相对稳定，平均为14.5±4.9mg/24小时（即处于正常尿THP排泄的下限）。在移植肾功能延迟出现且原因不明并伴有尿THP排泄极度减少的情况下，无论功能恢复是自发的还是由治疗引起的，其特征都是尿THP排泄持续增加。与间质性排斥反应相关时，尿THP排泄似乎不是一个推荐的诊断参数。然而，每日测量尿THP适用于监测移植肾的功能状态。
