Duława J, Kokot F, Kokot M, Pander H
Department of Nephrology, Endocrinology and Metabolic Diseases, Silesian University Medical School, Katowice, Poland.
J Hum Hypertens. 1998 Sep;12(9):635-7. doi: 10.1038/sj.jhh.1000680.
Tamm-Horsfall protein (THP) is a glycoprotein that is exclusively produced by the kidney in the thick ascending limb of Henle's loop (TAHL). Disturbances of TAHL function are associated with decreased urinary THP excretion. It is well known that renal function declines with advancing age. Moreover, it is suggested that THP may play a role in the pathophysiology of hypertension. The aim of this study was to assess urinary excretion of THP (U-THP) in healthy and hypertensive elderly patients. Fifteen young healthy subjects (YHS), 15 young hypertensive patients (YHT), 15 older normotensive (>60 years) subjects (OHS) and 31 older (>60 years) hypertensive patients (OHT) were examined. In all subjects 24-h urinary volume (UV), U-THP and creatinine (U-Cr), specific gravity of urine (U-SG), serum creatinine (S-Cr), and mean arterial pressure (MAP) were assessed. THP urinary excretion was significantly decreased in normotensive elderly patients, but not in hypertensive ones. Higher U-THP in the elderly hypertensive as compared with the elderly normotensive patients seems to be more the consequence than the cause of arterial hypertension.
Tamm-Horsfall蛋白（THP）是一种糖蛋白，仅由肾脏的髓袢升支粗段（TAHL）产生。TAHL功能紊乱与尿THP排泄减少有关。众所周知，肾功能会随着年龄的增长而下降。此外，有研究表明THP可能在高血压的病理生理学中发挥作用。本研究的目的是评估健康老年患者和高血压老年患者的尿THP排泄情况。研究检查了15名年轻健康受试者（YHS）、15名年轻高血压患者（YHT）、15名年龄较大的血压正常（>60岁）受试者（OHS）和31名年龄较大（>60岁）的高血压患者（OHT）。对所有受试者评估了24小时尿量（UV）、尿THP和肌酐（U-Cr）、尿比重（U-SG）、血清肌酐（S-Cr）和平均动脉压（MAP）。血压正常的老年患者尿THP排泄显著减少，但高血压老年患者未出现这种情况。与血压正常的老年患者相比，老年高血压患者尿THP较高似乎更多是动脉高血压的结果而非原因。
