Covelli V, D'Andrea L, Savastano S, Valentino R, Tommaselli A P, Selleri A, Massari F, Lombardi G
Chair of Neurology I, Medical School University Federico II, Naples, Italy.
Acta Neurol (Napoli). 1994 Jun;16(3):79-86.
We previously reported nocturnal plasma IL-1 beta (beta) increases during sleep in absence of stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis. In this paper we evaluate the presence of plasma IL-1 beta secretion in nine healthy volunteers (mean age 31.2 +/- 4.2) during post-prandial naps, after the administration of zolpidem, a benzodiazepine receptorial agonist. Although a significant increase in IL-1 beta plasma levels during spontaneous sleep was present in only four subjects when compared to those obtained during wake and induced-sleep, spontaneous sleep IL-1 beta mean plasma levels appeared slightly higher than both wake and induced-sleep values. Moreover, a negative correlation was present between IL-1 beta and cortisol (F) values obtained during the early afternoon (r = 7; p < 0.05). Our findings are consistent with a possible association of IL-1 beta secretion to physiologic sleep also during daytime spontaneous naps, with the presence of F influence on this phenomenon, and with the lack of IL-1 beta association to daytime naps after sleep-inducer pharmacological agents.
我们之前报道过，在没有应激诱导的下丘脑-垂体-肾上腺（HPA）轴激活的情况下，睡眠期间夜间血浆白细胞介素-1β（IL-1β）会增加。在本文中，我们评估了9名健康志愿者（平均年龄31.2±4.2岁）在餐后小睡期间、服用苯二氮䓬受体激动剂唑吡坦后血浆IL-1β的分泌情况。与清醒和诱导睡眠期间相比，只有4名受试者在自发睡眠期间IL-1β血浆水平显著升高，不过自发睡眠时IL-1β的平均血浆水平似乎略高于清醒和诱导睡眠时的值。此外，下午早些时候测得的IL-1β与皮质醇（F）值之间存在负相关（r = 7；p < 0.05）。我们的研究结果表明，白天自发小睡期间，IL-1β的分泌可能也与生理性睡眠有关，F对这一现象有影响，且睡眠诱导药物作用后的白天小睡与IL-1β无关。
