Covelli V, Cannuscio B, Munno I, Altamura M, Decandia P, Pellegrino N M, Maffione A B, Savastano S, Lombardi G
Clnica Neurologica E, Università di Napoli, Italy.
Acta Neurol (Napoli). 1991 Dec;13(6):520-6.
Cytokines (CKs) are involved in the mechanisms of sleep induction, and, in particular, interleukin-1 (IL-1) and tumor necrosis factor-alpha seem to play an important role in the slow-wave sleep. Here are reported two cases of normal sleep and altered sleep in which plasma levels of IL-1 beta have been determined. In the subject with a normal sleep a dramatic increase of this CK has been observed, while beta-endorphin levels were reduced. In the light of these findings, the role of sleep in the host protection is discussed.
细胞因子（CKs）参与睡眠诱导机制，特别是白细胞介素-1（IL-1）和肿瘤坏死因子-α似乎在慢波睡眠中起重要作用。本文报道了两例睡眠正常和睡眠改变的病例，其中测定了血浆IL-1β水平。在睡眠正常的受试者中，观察到这种细胞因子显著增加，而β-内啡肽水平降低。根据这些发现，讨论了睡眠在宿主保护中的作用。
