Illich P A, Salinas J A, Grau J W
Department of Psychology, Texas A&M University, College Station 77843.
Behav Neural Biol. 1994 Sep;62(2):140-50. doi: 10.1016/s0163-1047(05)80035-4.
Prior research has shown that a conditioned antinociceptive response can be established in spinalized rats by pairing stimulation to one hind leg (the conditioned stimulus, or CS) with tailshock (the unconditioned stimulus, or US). This suggests that spinal mechanisms can support classical conditioning. It is well known that in intact subjects, classical conditioning is undermined by preexposure to the CS (latent inhibition) or the concurrent presentation of either a more salient CS (overshadowing) or one that has already been associated with the US (blocking). In the present paper we show that these manipulations have a similar impact on the acquisition of a conditioned antinociceptive response in spinalized rats. These findings imply that similar principles may govern the acquisition of a conditioned response across different levels of the nervous system.
先前的研究表明，通过将对一条后腿的刺激（条件刺激，或CS）与尾部电击（非条件刺激，或US）配对，可在脊髓损伤的大鼠中建立条件性抗伤害感受反应。这表明脊髓机制能够支持经典条件作用。众所周知，在完整的实验对象中，经典条件作用会因对CS的预暴露（潜伏抑制）或同时呈现更显著的CS（遮蔽）或已与US相关联的CS（阻断）而受到破坏。在本文中，我们表明这些操作对脊髓损伤大鼠条件性抗伤害感受反应的获得有类似影响。这些发现意味着类似的原理可能支配着不同神经系统水平上条件反应的获得。
