Grau J W, Salinas J A, Illich P A, Meagher M W
Department of Psychology, Texas A&M University, College Station 77843.
Behav Neurosci. 1990 Jun;104(3):489-94. doi: 10.1037//0735-7044.104.3.489.
Prior research suggests that associative and memorial processes can modulate the activation of the endogenous antinociceptive systems. It has been generally assumed that forebrain systems play an essential role in mediating the impact of these processes. The present experiments explored whether the behavioral effects indicative of associative and memorial processes can be obtained in spinalized rats. Experiment 1 demonstrated that a conditioned nonopioid antinociception can be established after rats have experienced a spinal transection at the level of the 2nd thoracic vertebrae. Experiment 2 showed that a postshock distractor can speed the decay of shock-induced antinociception in the spinalized rat. These findings suggest that the circuitry needed to obtain associative and memorylike effects is present within the spinal cord.
先前的研究表明，联想和记忆过程可以调节内源性抗伤害感受系统的激活。人们普遍认为，前脑系统在介导这些过程的影响中起着至关重要的作用。目前的实验探讨了在脊髓横断的大鼠中是否能获得指示联想和记忆过程的行为效应。实验1表明，在大鼠经历第二胸椎水平的脊髓横断后，可以建立条件性非阿片类抗伤害感受。实验2表明，电击后分心物可以加速脊髓横断大鼠电击诱导的抗伤害感受的消退。这些发现表明，获得联想和记忆样效应所需的神经回路存在于脊髓内。
