Lyon K F
Department of Dentistry, Mesa Veterinary Hospital, AZ 85201.
J Vet Dent. 1994 Mar;11(1):25-7.
Lymphoplasmacytic stomatitis and gingivitis was diagnosed in an 8-year old female domestic shorthair. The cat had evidence of severe generalized inflammation of the oral cavity. Biopsy samples were evaluated and displayed a lichenoid, interface stomatitis which was predominantly lymphoplasmacytic. Serum protein electrophoresis confirmed a monoclonal gammopathy. Urine protein electrophoresis confirmed Bence-Jones proteinuria. Protein electrophoresis was used to diagnose monoclonal gammopathy (the production of a monoclonal immunoglobulin, or paraprotein, which is associated with a characteristic "M" protein spike on serum electrophoresis). Diseases associated with monoclonal gammopathy are similar in the dog and cat. Alkylating agent chemotherapy is used to rapidly reduce paraprotein concentrations in multiple myeloma. Multiple myeloma is the most common disorder associated with monoclonal gammopathy. This condition is less common in the cat, compared to the dog. This report examines the diagnosis and treatment of multiple myeloma in a cat presenting with severe stomatitis.
一只8岁的雌性家养短毛猫被诊断为淋巴浆细胞性口炎和牙龈炎。这只猫有口腔严重全身性炎症的迹象。对活检样本进行评估，显示为苔藓样界面性口炎，主要为淋巴浆细胞性。血清蛋白电泳证实存在单克隆丙种球蛋白病。尿蛋白电泳证实存在本-周蛋白尿。蛋白电泳用于诊断单克隆丙种球蛋白病（产生单克隆免疫球蛋白或副蛋白，与血清电泳上特征性的“M”蛋白峰相关）。犬猫中与单克隆丙种球蛋白病相关的疾病相似。烷化剂化疗用于快速降低多发性骨髓瘤中的副蛋白浓度。多发性骨髓瘤是与单克隆丙种球蛋白病相关的最常见疾病。与犬相比，这种情况在猫中较少见。本报告探讨了一只患有严重口炎的猫的多发性骨髓瘤的诊断和治疗。
