喷他卡因的胃抗溃疡活性：可能的作用机制。
Gastric antiulcer activity of pentacaine: possible mechanism of action.
作者信息
Nosál'ová V, Babul'ová A
机构信息
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
出版信息
Physiol Res. 1994;43(3):181-6.
The effect of pentacaine on different models of gastric and duodenal damage and on gastric acid secretion was studied after oral and parenteral administration. A proportional involvement of local and systemic effects of pentacaine was found in phenylbutazone-induced and cold-resistant stress-induced lesions, whereas in ethanol-induced lesions oral administration was the only effective way. On the other hand, duodenal lesions and gastric acid secretion were substantially affected by parenteral administration. The possible mechanisms involved in these differences are discussed.
研究了喷他卡因经口服和胃肠外给药后对不同模型的胃和十二指肠损伤以及胃酸分泌的影响。在保泰松诱导和耐冷应激诱导的损伤中发现喷他卡因的局部和全身作用成比例参与，而在乙醇诱导的损伤中，口服给药是唯一有效的途径。另一方面，胃肠外给药对十二指肠损伤和胃酸分泌有显著影响。讨论了这些差异可能涉及的机制。
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