Ergaz Z, Arad I
Department of Neonatology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
Biol Neonate. 1994;66(2-3):71-5. doi: 10.1159/000244092.
The rate of hemolysis of transfused adult red blood cells in the premature circulation may be higher than in the native circulation and produce a significant bilirubin load on the immature liver during the first days of life with consequent hyperbilirubinemia. The association between the transfusion of packed red blood cells and consequent change of serum bilirubin level was evaluated in 35 premature infants with birth weight of < 1,250 g during the first 10 days of life, using the analysis of variance method. There was a significant increase of bilirubin level with a mean of 24.3 mumol/l following packed red blood cells transfusion. Birth weight had a significant negative effect and mechanical ventilation for > 2 days had a significant positive effect on bilirubin levels; however, the changes were of small magnitude. The results of our study indicate that a rise of bilirubin level following blood transfusion to very low birth weight infants during the early neonatal period should be anticipated.
在早产循环中，输注的成人红细胞的溶血速率可能高于在自身循环中的溶血速率，并且在出生后的头几天会给未成熟的肝脏带来大量胆红素负荷，从而导致高胆红素血症。采用方差分析法，对35例出生体重<1250g的早产儿在出生后10天内输注浓缩红细胞与血清胆红素水平变化之间的关系进行了评估。输注浓缩红细胞后，胆红素水平显著升高，平均升高24.3μmol/L。出生体重对胆红素水平有显著的负面影响，机械通气超过2天对胆红素水平有显著的正面影响；然而，这些变化幅度较小。我们的研究结果表明，应预计到在新生儿早期给极低出生体重儿输血后胆红素水平会升高。
