Michel G, Thuret I, Chambost H, Scheiner C, Mary C, Perrimond H
Department of Pediatric Haematology, Children Hospital La Timone, Marseille, France.
Bone Marrow Transplant. 1994 Sep;14(3):455-7.
We report a clinically isolated toxoplasma pneumonitis in a child treated by HLA haplo-mismatched BMT. Conditioning consisted of TBI, cytarabine and melphalan. The BM graft was T-depleted and the boy received iv moAb antiLFA1 and antiCD2. The clinical course of pneumonitis was characterised by an early onset (day 28) and a rapidly overwhelming course. Donor and recipient had pre-graft IgG Ab against toxoplasma without IgM. These Abs had completely disappeared from the serum of the patient at the time of pneumonitis. PCR amplification detected the B1 gene of Toxoplasma gondii in the patient's PBMC from day 28.
我们报告了1例接受HLA单倍型不匹配骨髓移植治疗的儿童临床孤立性弓形虫肺炎。预处理方案包括全身照射、阿糖胞苷和美法仑。骨髓移植物进行了T细胞去除，该男孩接受了静脉注射抗LFA1和抗CD2单克隆抗体。肺炎的临床过程特点为发病早（第28天）且病情迅速发展。供体和受体移植前有针对弓形虫的IgG抗体而无IgM抗体。在肺炎发生时，这些抗体已从患者血清中完全消失。从第28天起，PCR扩增在患者外周血单个核细胞中检测到刚地弓形虫的B1基因。
