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Hemoglobinuria in rats: a sensitive test of renal filtering and absorption of PEG-hemoglobin, a red blood cell substitute.

作者信息

Gilbert C, Nho K, Johnson M, Linberg R, Shorr R

机构信息

Enzon, Inc., Piscataway, NJ 08854.

出版信息

Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):535-41. doi: 10.3109/10731199409117881.

DOI:10.3109/10731199409117881
PMID:7994375
Abstract

Hemoglobinuria, defined as hemoglobin or hemoglobin subunits in the urine, is an easily monitored, sensitive indicator of renal handling of hemoglobin-based blood substitutes. Hemoglobin tetramer dissociation increases filtration by the kidneys. When the rate of filtration exceeds reabsorption, hemoglobinuria occurs. This study investigates the renal filtration and absorption of polyethylene glycol-modified bovine hemoglobin by monitoring for hemoglobinuria in several model systems.

摘要

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