聚乙二醇修饰牛血红蛋白的生产：经济性与可行性
Production of PEG-modified bovine hemoglobin: economics and feasibility.
作者信息
Bradley R, Sloshberg S, Nho K, Czuba B, Szesko D, Shorr R
机构信息
Enzon, Inc., Piscataway, NJ 08854.
出版信息
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):657-67. doi: 10.3109/10731199409117896.
PMID:7994387
Abstract
Bovine hemoglobin has many advantages as a blood substitute: a) it's ready availability; b) it's low cost; c) it's oxygen carrying capacity; and d) the ease with which it can be modified with polyethylene glycol (PEG) to improve its pharmacokinetic profile. This study investigates the potential of PEG-modified bovine hemoglobin as a cost-effective blood substitute.
摘要
牛血红蛋白作为一种血液替代品有诸多优点
a) 易于获取；b) 成本低廉；c) 具有携氧能力；d) 易于用聚乙二醇（PEG）进行修饰以改善其药代动力学特性。本研究探讨了聚乙二醇修饰的牛血红蛋白作为一种经济高效的血液替代品的潜力。
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