Chand N, Diamantis W, Nolan K, Pillar J, Sofia R D
Wallace Laboratories, Division of Carter-Wallace, Inc., New Jersey 08512.
Res Commun Mol Pathol Pharmacol. 1994 Aug;85(2):209-16.
A simple, noninvasive, bias-flow ventilated wholebody plethysmographic technique and noninvasive pulmonary analyzer (Buxco dyspnea monitor) were used to quantitate allergic dyspnea in chronically sensitized freely moving guinea pigs. In this study, the effect of azelastine on aeroallergen-induced dyspnea in allergic guinea pigs was investigated. Aeroallergen challenge produced severe dyspnea which was characterized by a 390% increase in the amplitude of pseudo flow signal, a 93% increase in box pressure (delta P) and a 68% decline in relaxation time; these changes signify a tremendous increase in the effort of breathing. The oral administration of azelastine (1 mg/kg) two hours before aeroallergen provocation significantly inhibited allergic dyspnea in this acute allergic asthma model. This technique permits quantitative measurement of the severity of the airway allergic responses in freely moving guinea pigs.
采用一种简单、无创、偏流通气的全身体积描记技术和无创肺分析仪（Buxco呼吸困难监测仪）对慢性致敏的自由活动豚鼠的过敏性呼吸困难进行定量分析。在本研究中，研究了氮卓斯汀对变应性豚鼠气源性变应原诱发的呼吸困难的影响。气源性变应原激发可产生严重的呼吸困难，其特征为伪流信号幅度增加390%、箱压（ΔP）增加93%以及松弛时间缩短68%；这些变化表明呼吸努力显著增加。在气源性变应原激发前两小时口服氮卓斯汀（1 mg/kg）可显著抑制该急性过敏性哮喘模型中的过敏性呼吸困难。该技术可对自由活动豚鼠气道过敏反应的严重程度进行定量测量。
