通过偏流通气全身体积描记法对未束缚豚鼠气源性变应原诱导的呼吸困难进行表征。

Characterization of aeroallergen-induced dyspnea in unrestrained guinea pigs by bias-flow-ventilated whole body plethysmography.

作者信息

Chand N, Nolan K, Pillar J, Zomask M, Diamantis W, Sofia R D

机构信息

Wallace Laboratories, Division of Carter-Wallace Inc., Cranbury, NJ 08512.

出版信息

Agents Actions. 1992 Nov;37(3-4):184-7. doi: 10.1007/BF02028104.

DOI:10.1007/BF02028104

PMID:1295366

Abstract

Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pressure signal to drop from its peak to 1/3 of its peak value). All of these lung dysfunction changes were highly significant (P < 0.001). Pyrilamine (1 mg/kg, p.o., -2 h) inhibited dyspnea (delta P and delta F) by 50-53%. This technique allows quantitative analysis of allergic dyspnea in conscious, unrestrained guinea pigs.

摘要

变应原诱导的豚鼠呼吸困难与箱内压力波动幅度增加（212%）、伪流量信号增加（604%）以及松弛时间（箱内压力信号从峰值降至其峰值的1/3所需时间）下降80%（从0.19秒降至0.04秒）相关。所有这些肺功能障碍变化均具有高度显著性（P < 0.001）。扑尔敏（1毫克/千克，口服，-2小时）可使呼吸困难（ΔP和ΔF）减轻50 - 53%。该技术可对清醒、不受束缚的豚鼠的过敏性呼吸困难进行定量分析。