Chand N, Nolan K, Pillar J, Zomask M, Diamantis W, Sofia R D
Wallace Laboratories, Division of Carter-Wallace Inc., Cranbury, NJ 08512.
Agents Actions. 1992 Nov;37(3-4):184-7. doi: 10.1007/BF02028104.
Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pressure signal to drop from its peak to 1/3 of its peak value). All of these lung dysfunction changes were highly significant (P < 0.001). Pyrilamine (1 mg/kg, p.o., -2 h) inhibited dyspnea (delta P and delta F) by 50-53%. This technique allows quantitative analysis of allergic dyspnea in conscious, unrestrained guinea pigs.
变应原诱导的豚鼠呼吸困难与箱内压力波动幅度增加（212%）、伪流量信号增加（604%）以及松弛时间（箱内压力信号从峰值降至其峰值的1/3所需时间）下降80%（从0.19秒降至0.04秒）相关。所有这些肺功能障碍变化均具有高度显著性（P < 0.001）。扑尔敏（1毫克/千克，口服，-2小时）可使呼吸困难（ΔP和ΔF）减轻50 - 53%。该技术可对清醒、不受束缚的豚鼠的过敏性呼吸困难进行定量分析。
