免疫抑制治疗的进展
Therapeutic advances in immunosuppression.
作者信息
Thomson A W, Forrester J V
机构信息
Department of Surgery, University of Pittsburgh Medical Centre, PA 15213-2582.
出版信息
Clin Exp Immunol. 1994 Dec;98(3):351-7. doi: 10.1111/j.1365-2249.1994.tb05496.x.
Abstract
Immunosuppressive therapy is appropriate for the prevention or reversal of allograft rejection, and for the treatment of autoimmune disorders and allergic disease. Recent advances in our understanding of the cellular and molecular mechanisms that regulate immune responses have paralleled elucidation of the modes of action of a variety of therapeutic immunosuppressive agents, both 'old' and new. These developments have identified potential targets for more refined and specific intervention strategies that are now being tested in the clinic.
摘要
免疫抑制疗法适用于预防或逆转同种异体移植排斥反应，以及治疗自身免疫性疾病和过敏性疾病。我们对调节免疫反应的细胞和分子机制的理解取得了最新进展，与此同时，对各种新旧治疗性免疫抑制剂的作用模式也有了更清晰的认识。这些进展确定了更精确、更具特异性的干预策略的潜在靶点，目前正在临床中进行测试。
相似文献
1
Therapeutic advances in immunosuppression.免疫抑制治疗的进展
Clin Exp Immunol. 1994 Dec;98(3):351-7. doi: 10.1111/j.1365-2249.1994.tb05496.x.
2
Immunosuppression in organ transplantation.器官移植中的免疫抑制
Semin Pediatr Surg. 1993 Nov;2(4):206-7.
3
Immunologic basis of allograft rejection and immunosuppressive agents in intestinal transplantation.肠道移植中同种异体移植排斥反应的免疫基础及免疫抑制剂
Minerva Pediatr. 2009 Jun;61(3):293-303.
4
Update in immunosuppression.免疫抑制的最新进展。
Nephrol Nurs J. 2002 Jun;29(3):261-7.
5
The Evolution of Lung Transplant Immunosuppression.肺移植免疫抑制的演变。
Drugs. 2018 Jul;78(10):965-982. doi: 10.1007/s40265-018-0930-6.
6
Immunosuppression in the era of biological agents.生物制剂时代的免疫抑制。
Adv Exp Med Biol. 2012;741:60-72. doi: 10.1007/978-1-4614-2098-9_5.
7
Immunosuppression for lung transplantation.肺移植的免疫抑制
Proc Am Thorac Soc. 2009 Jan 15;6(1):47-53. doi: 10.1513/pats.200808-096GO.
8
Current status of immunosuppressive minimization and tolerance strategies.免疫抑制最小化及耐受策略的当前状况
Transpl Int. 2015 Aug;28(8):889-90. doi: 10.1111/tri.12624.
9
Conventional and novel approaches to immunosuppression.传统和新型免疫抑制方法。
Clin Chest Med. 2011 Jun;32(2):265-77. doi: 10.1016/j.ccm.2011.02.012.
10
Present state of immunosuppressive therapy in liver transplant recipients.肝移植受者免疫抑制治疗的现状。
Liver Transpl. 2011 Nov;17 Suppl 3:S1-9. doi: 10.1002/lt.22410.
引用本文的文献
1
Effects of an immunosuppressive treatment on the rat prostate.免疫抑制治疗对大鼠前列腺的影响。
Drug Des Devel Ther. 2016 Sep 12;10:2899-2915. doi: 10.2147/DDDT.S111695. eCollection 2016.
2
Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.白藜芦醇和姜黄素通过CD28/CTLA-4和CD80共刺激途径抑制免疫反应。
Clin Exp Immunol. 2007 Jan;147(1):155-63. doi: 10.1111/j.1365-2249.2006.03257.x.
本文引用的文献
1
Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured vessels.
Transplantation. 1993 Jun;55(6):1409-18. doi: 10.1097/00007890-199306000-00037.
2
Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat.人类白细胞介素-1受体拮抗剂基因内含子2的多态性是由一个86碱基对串联重复序列的数目可变引起的。
Hum Genet. 1993 May;91(4):403-4. doi: 10.1007/BF00217368.
3
Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT.糖皮质激素通过干扰核转录因子AP-1和NF-AT对人白细胞介素2（IL-2）基因进行负转录调控。
J Clin Invest. 1993 Apr;91(4):1481-9. doi: 10.1172/JCI116353.
4
Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin.经口服卵清蛋白诱导耐受的T淋巴细胞无反应性的直接证据。
Eur J Immunol. 1993 Apr;23(4):935-42. doi: 10.1002/eji.1830230426.
5
Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.经鼻给予视网膜抗原可抑制实验性过敏性葡萄膜视网膜炎中的炎症反应。关于经鼻给予视网膜抗原诱导耐受的初步报告。
Br J Ophthalmol. 1993 Mar;77(3):171-5. doi: 10.1136/bjo.77.3.171.
6
An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.人类肿瘤坏死因子α启动子区域内的一个等位基因多态性与HLA A1、B8和DR3等位基因密切相关。
J Exp Med. 1993 Feb 1;177(2):557-60. doi: 10.1084/jem.177.2.557.
7
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.免疫抑制药物所允许的供体细胞嵌合现象：器官移植的新视角。
Immunol Today. 1993 Jun;14(6):326-32. doi: 10.1016/0167-5699(93)90054-o.
8
Effects of oral administration of type II collagen on rheumatoid arthritis.口服II型胶原蛋白对类风湿性关节炎的影响。
Science. 1993 Sep 24;261(5129):1727-30. doi: 10.1126/science.8378772.
9
In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens.人CD4⁺T细胞识别屋尘螨过敏原时的体内克隆优势及有限的T细胞受体使用情况
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8214-8. doi: 10.1073/pnas.90.17.8214.
Zotero 插件