Thomson A W, Forrester J V
Department of Surgery, University of Pittsburgh Medical Centre, PA 15213-2582.
Clin Exp Immunol. 1994 Dec;98(3):351-7. doi: 10.1111/j.1365-2249.1994.tb05496.x.
Immunosuppressive therapy is appropriate for the prevention or reversal of allograft rejection, and for the treatment of autoimmune disorders and allergic disease. Recent advances in our understanding of the cellular and molecular mechanisms that regulate immune responses have paralleled elucidation of the modes of action of a variety of therapeutic immunosuppressive agents, both 'old' and new. These developments have identified potential targets for more refined and specific intervention strategies that are now being tested in the clinic.
免疫抑制疗法适用于预防或逆转同种异体移植排斥反应，以及治疗自身免疫性疾病和过敏性疾病。我们对调节免疫反应的细胞和分子机制的理解取得了最新进展，与此同时，对各种新旧治疗性免疫抑制剂的作用模式也有了更清晰的认识。这些进展确定了更精确、更具特异性的干预策略的潜在靶点，目前正在临床中进行测试。
