Starzl T E, Demetris A J, Murase N, Thomson A W, Trucco M, Ricordi C
Dept of Surgery, University of Pittsburgh Health Science Center, PA 15213.
Immunol Today. 1993 Jun;14(6):326-32. doi: 10.1016/0167-5699(93)90054-o.
One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.
器官移植领域的一种观点认为，免疫抑制药物可通过促使一种此前未被认识的细胞迁移和微嵌合现象的共同机制出现、持续存在，且在某些情况下变得不依赖药物，从而诱导免疫耐受。人们已经认识到，不同器官对细胞排斥的易感性存在差异，这些器官诱导供体特异性无反应性的能力各不相同，这反映了它们迁移白细胞的相对含量。在此，托马斯·斯塔兹尔及其同事讨论了这种嵌合现象如何能够解释移植免疫学中的诸多谜团。
