Malbrain M L, Lambrecht G L, Daelemans R, Lins R L, Hermans P, Zachée P
Department of Internal Medicine, Stuivenberg General Hospital, Antwerpen, Belgium.
Clin Nephrol. 1994 Sep;42(3):163-9.
Primary extranodal non-Hodgkin's lymphoma (p-EN-NHL) of the kidneys with acute renal failure as the only manifestation is very rare. The origin of neoplastic lymphoid cells in the kidneys, organs normally free of lymphoid tissue, is an unsolved problem. A literature review over the last ten years revealed only 9 adult cases, including ours that match the usual criteria: (1) renal failure as the initial presentation, (2) bilateral enlargement of the kidneys without obstruction and other organ or nodal involvement, (3) diagnosis only made by renal biopsy, (4) absence of other causes of renal failure, and (5) rapid improvement of renal function after radiotherapy or, as in our case, systemic chemotherapy. Autopsy on two patients confirmed that p-EN-NHL of the kidneys without dissemination does exist as a separate entity.
以急性肾衰竭为唯一表现的原发性肾外非霍奇金淋巴瘤（p-EN-NHL）非常罕见。肾脏中肿瘤性淋巴细胞的起源，而肾脏通常是没有淋巴组织的器官，这是一个尚未解决的问题。过去十年的文献综述仅发现9例成人病例，包括我们的病例，这些病例符合以下通常标准：（1）以肾衰竭为首发表现；（2）双肾肿大，无梗阻且无其他器官或淋巴结受累；（3）仅通过肾活检确诊；（4）无其他肾衰竭原因；（5）放疗后肾功能迅速改善，或如我们的病例，全身化疗后肾功能迅速改善。对两名患者的尸检证实，无播散的肾脏p-EN-NHL确实作为一个独立的实体存在。
