Yasar S, Bergman J
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Medical School, Baltimore.
Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):768-73. doi: 10.1038/clpt.1994.207.
l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.
左旋司来吉兰在大鼠和猴子身上具有剂量依赖性的苯丙胺和甲基苯丙胺样辨别刺激特性。然而，这些作用仅在远高于左旋司来吉兰临床相关剂量范围的剂量下才会出现，并且很可能反映了其向苯丙胺类产物的代谢转化。鉴于其产生苯丙胺样作用的效力较弱且起效缓慢，左旋司来吉兰似乎没有苯丙胺样滥用潜力，并且已经在帕金森综合征的治疗中使用了20多年，没有滥用的报道，这也许并不奇怪。
