Winger G D, Yasar S, Negus S S, Goldberg S R
Department of Pharmacology, University of Michigan Medical School, Ann Arbor.
Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):774-80. doi: 10.1038/clpt.1994.208.
l-Deprenyl and its stereoisomer d-deprenyl did not maintain intravenous self-administration behavior in rhesus monkeys. In contrast, l-methamphetamine, the major metabolite of l-deprenyl, as well as the baseline drug, cocaine, maintained high rates of intravenous self-administration behavior. Treatment with l-deprenyl doses up to 1.0 mg/kg before self-administration sessions failed to alter self-administration of either cocaine or l-methamphetamine. Thus l-deprenyl did not appear to have cocaine- or methamphetamine-like reinforcing properties in monkeys and was ineffective in altering established patterns of psychomotor-stimulant self-administration behavior. These results support clinical findings that despite long-term use of l-deprenyl for the treatment of Parkinson's disease by large numbers of patients, no instances of abuse have been documented. l-Deprenyl has recently been suggested as a potential medication for the treatment of various types of drug abuse, including cocaine abuse, but its failure to produce selective effects in decreasing cocaine or methamphetamine self-administration behavior in the present experiments makes such an application seem unlikely.
左旋司来吉兰及其立体异构体右旋司来吉兰在恒河猴中未维持静脉自我给药行为。相比之下，左旋司来吉兰的主要代谢产物左旋甲基苯丙胺以及基准药物可卡因则维持了较高的静脉自我给药行为率。在自我给药实验前给予高达1.0毫克/千克的左旋司来吉兰剂量，未能改变可卡因或左旋甲基苯丙胺的自我给药行为。因此，左旋司来吉兰在猴子中似乎不具有类似可卡因或甲基苯丙胺的强化特性，并且在改变既定的精神运动兴奋剂自我给药行为模式方面无效。这些结果支持了临床研究结果，即尽管大量患者长期使用左旋司来吉兰治疗帕金森病，但尚未有滥用的记录。左旋司来吉兰最近被提议作为治疗包括可卡因滥用在内的各种药物滥用的潜在药物，但在本实验中它未能产生选择性作用来减少可卡因或甲基苯丙胺的自我给药行为，这使得这种应用似乎不太可能。
