Schneider L S, Tariot P N, Goldstein B
Department of Psychiatry, University of Southern California, Los Angeles 90033.
Clin Pharmacol Ther. 1994 Dec;56(6 Pt 2):750-6. doi: 10.1038/clpt.1994.205.
This article briefly reviews the clinical aspects and rationale for therapy with l-deprenyl for several neuropsychiatric conditions, including major depression, Alzheimer's disease, and Parkinson's disease. The rationale for the use of l-deprenyl in these conditions is discussed, and evidence for efficacy is reviewed. Lastly, there is a review of the lack of evidence for l-deprenyl's abuse potential and its use as putative nonspecific cognitive enhancer, a so-called "smart drug." Although l-deprenyl itself appears to have no abuse potential, it is theoretically possible that it might potentiate the actions and frequency of dosage and use of various drugs of abuse or dependence. This is as yet an underresearched area, and more work is required.
本文简要回顾了左旋司来吉兰用于治疗几种神经精神疾病（包括重度抑郁症、阿尔茨海默病和帕金森病）的临床情况及治疗原理。文中讨论了在这些疾病中使用左旋司来吉兰的原理，并对其疗效证据进行了综述。最后，对左旋司来吉兰缺乏滥用潜力的证据以及其作为所谓的非特异性认知增强剂（即“聪明药”）的使用情况进行了综述。虽然左旋司来吉兰本身似乎没有滥用潜力，但理论上它可能会增强各种滥用或成瘾药物的作用、剂量使用频率。这仍是一个研究不足的领域，需要开展更多工作。
