Shirouzu K, Isomoto H, Morodomi T, Ogata Y, Araki Y, Kakegawa T
First Department of Surgery, Kurume University School of Medicine, Japan.
Dis Colon Rectum. 1994 Dec;37(12):1245-9. doi: 10.1007/BF02257790.
This study was designed to clarify the characteristics of large bowel cancer developing after radiotherapy for uterine cervical cancer.
A retrospective chart review was performed.
The latent period was a mean of 20.5 years. The most common site was in the rectum (16/32). Mucin-producing carcinoma was observed in 53.1 percent, with an especially high rate of 75 percent in the rectum. Histologic radiation damage was also demonstrated at a high rate of 64.3 percent.
It was difficult to judge from clinicopathologic findings whether large bowel cancer developed with relation to radiation effect. We emphasize, however, that the characteristics are different from ordinary large bowel cancer. Particular consideration should be given to the high incidence of mucin-producing carcinoma.
本研究旨在阐明子宫颈癌放疗后发生的大肠癌的特征。
进行回顾性病历审查。
潜伏期平均为20.5年。最常见的部位是直肠（16/32）。53.1%的病例观察到黏液腺癌，在直肠中的发生率特别高，为75%。组织学辐射损伤的发生率也很高，为64.3%。
从临床病理结果很难判断大肠癌的发生是否与辐射效应有关。然而，我们强调其特征与普通大肠癌不同。应特别考虑黏液腺癌的高发病率。
