Rogstad B
Medical Department, Buskerud Central Hospital, Drammen, Norway.
Eur J Clin Pharmacol. 1994;46(6):487-9. doi: 10.1007/BF00196102.
Lisinopril has been compared with slow-release nifedipine in a 16-week double-blind, randomized, parallel-group study involving 102 patients with mild to moderate hypertension. Sitting systolic and diastolic blood pressures were reduced 6 and 5 mmHg more by lisinopril than by nifedipine over 12 weeks monotherapy. After 12 weeks a greater proportion of patients taking lisinopril was controlled (sitting diastolic blood pressure below 95 mm Hg) than in those taking nifedipine. As a result, 17% of those taking lisinopril and 38% of those taking nifedipine required additional therapy with hydrochlorothiazide. The addition of hydrochlorothiazide resulted in similar response rates in the lisinopril and nifedipine groups (89% and 75% respectively). The rate of reporting of adverse events considered to be drug-related and the rate of withdrawals were similar for both treatments. Cough was more often reported with lisinopril and headache, sweating, and hot flushes with nifedipine. We conclude that once-daily titrated doses of lisinopril produced better control of blood pressure than twice-daily titrated doses of nifedipine.
在一项为期16周的双盲、随机、平行组研究中，将赖诺普利与缓释硝苯地平进行了比较，该研究纳入了102例轻度至中度高血压患者。在12周的单药治疗中，赖诺普利使坐位收缩压和舒张压分别比硝苯地平多降低6 mmHg和5 mmHg。12周后，服用赖诺普利的患者中血压得到控制（坐位舒张压低于95 mmHg）的比例高于服用硝苯地平的患者。结果，服用赖诺普利的患者中有17%、服用硝苯地平的患者中有38%需要加用氢氯噻嗪进行额外治疗。加用氢氯噻嗪后，赖诺普利组和硝苯地平组的反应率相似（分别为89%和75%）。两种治疗的药物相关不良事件报告率和停药率相似。服用赖诺普利时咳嗽的报告更为常见，而服用硝苯地平时头痛、出汗和潮热的报告更为常见。我们得出结论，每日一次滴定剂量的赖诺普利比每日两次滴定剂量的硝苯地平能更好地控制血压。
