Rossi G, Zanin L, Lippolt A, Pavan E, Pessina A C
Istituto di Medicina Clinica dell'Università di Padova.
G Ital Cardiol. 1994 Sep;24(9):1125-35.
Arterial hypertension is thought to derive from an interaction between genetic and environmental factors. Primary hypertension is currently deemed to be under complete polygenic control but highly heterogeneous both from the genetic and the pathophysiologic standpoint. In the last few years a widespread application of molecular medicine techniques to epidemiological genetic studies has led to unprecedented progress in unravelling the genetical basis of human hypertension. The current research strategies along with the most recent results in this field are reviewed.
动脉高血压被认为源于遗传因素与环境因素之间的相互作用。原发性高血压目前被认为完全受多基因控制,但从遗传和病理生理学角度来看都高度异质。在过去几年中,分子医学技术在流行病学基因研究中的广泛应用,在揭示人类高血压的遗传基础方面取得了前所未有的进展。本文综述了该领域目前的研究策略以及最新成果。