组织同种肾素
Tissue iso-renins.
作者信息
Ganten D, Hutchinson J S, Haebara H, Schelling P, Fischer H, Ganten U
出版信息
Clin Sci Mol Med Suppl. 1976 Dec;3:117s-120s. doi: 10.1042/cs051117s.
PMID:799550
Abstract
- Several extrarenal tissues contain enzymes which are similar to kidney renin: they hydrolyse angiotensinogen to form angiotensin I; they have characteristic substrate specificity; the physicochemical properties of kidney renin and of extrarenal tissue iso-renin are similar. 2. Results indicate that tissue iso-renins are part of a complex enzyme system with mainly local function. A possible biological role has been demonstrated in brain, adrenal gland and tissue culture.
摘要
- 几种肾外组织含有与肾脏肾素相似的酶：它们将血管紧张素原水解形成血管紧张素I；它们具有独特的底物特异性；肾脏肾素和肾外组织同工肾素的物理化学性质相似。2. 结果表明，组织同工肾素是一个主要具有局部功能的复杂酶系统的一部分。在脑、肾上腺和组织培养中已证实了其可能的生物学作用。
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