肾外来源的异肾素。“组织血管紧张素原酶系统”。

Iso-renin of extrarenal origin. "The tissue angiotensinogenase systems".

作者信息

Ganten D, Schelling P, Vecsei P, Ganten U

出版信息

Am J Med. 1976 May 31;60(6):760-72. doi: 10.1016/0002-9343(76)90890-1.

Abstract

Enzymes, similar to kidney renin, are present in extrarenal tissue of most mammals; they hydrolyze angiotensinogen to form angiotensin I. We suggest that these enzymes be called angiotensinogenases. Angiotensinogenase concentrations in extrarenal tissue can exceed those in the kidney. The enzyme has been obtained in pure crystalline form. Angiotensinogenases are part of a complex enzyme system which leads to local production of angiotensin. Results indicating a biologic role of the angiotensinogenase system in brain, adrenal gland, uterus and tissue culture are discussed.

摘要

与肾素类似的酶存在于大多数哺乳动物的肾外组织中；它们将血管紧张素原水解形成血管紧张素I。我们建议将这些酶称为血管紧张素原酶。肾外组织中的血管紧张素原酶浓度可能超过肾脏中的浓度。该酶已以纯结晶形式获得。血管紧张素原酶是导致血管紧张素局部产生的复杂酶系统的一部分。本文讨论了表明血管紧张素原酶系统在脑、肾上腺、子宫和组织培养中的生物学作用的结果。