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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Muiesan G, Magnani B, Agabiti-Rosei E, Alicandri C, Ambrosioni E, Miele N

Clin Sci Mol Med Suppl. 1976 Dec;3:529s-531s. doi: 10.1042/cs051529s.

The effects of timolol alone and in combination with a fixed dose of hydrochlorothiazide and amiloride have been studied in a double-blind, controlled study in fifty-four patients with mild to moderate essential hypertension. 2. After a 4 weeks placebo period patients were randomly assigned to enter groups receiving timolol alone (group A), hydrochlorothiazide + amiloride (group B) or timolol + hydrochlorothiazide + amiloride (group C). Each treatment was carried out for 6 weeks. 3. The use of timolol (10 mg), hydrochlorothiazide (25 mg) and amiloride (2-5 mg) in a combination tablet given twice daily gave better control of blood pressure in patients with mild to moderate essential hypertension than did equivalent dosages of timolol alone or of hydrochlorothiazide and amiloride. 4. Clinical and laboratory side effects were minimal.

在一项针对54例轻度至中度原发性高血压患者的双盲对照研究中，对单独使用噻吗洛尔以及噻吗洛尔与固定剂量的氢氯噻嗪和阿米洛利联合使用的效果进行了研究。2. 经过4周的安慰剂期后，患者被随机分配进入单独接受噻吗洛尔治疗的组（A组）、接受氢氯噻嗪+阿米洛利治疗的组（B组）或接受噻吗洛尔+氢氯噻嗪+阿米洛利治疗的组（C组）。每种治疗持续6周。3. 对于轻度至中度原发性高血压患者，每日服用两次的复方片剂中使用噻吗洛尔（10毫克）、氢氯噻嗪（25毫克）和阿米洛利（2 - 5毫克）比单独使用等量的噻吗洛尔或氢氯噻嗪与阿米洛利能更好地控制血压。4. 临床和实验室副作用极小。

Muiesan G, Magnani B, Agabiti-Rosei E, Alicandri C, Ambrosioni E, Miele N

Clin Sci Mol Med Suppl. 1976 Dec;3:529s-531s. doi: 10.1042/cs051529s.

The effects of timolol alone and in combination with a fixed dose of hydrochlorothiazide and amiloride have been studied in a double-blind, controlled study in fifty-four patients with mild to moderate essential hypertension. 2. After a 4 weeks placebo period patients were randomly assigned to enter groups receiving timolol alone (group A), hydrochlorothiazide + amiloride (group B) or timolol + hydrochlorothiazide + amiloride (group C). Each treatment was carried out for 6 weeks. 3. The use of timolol (10 mg), hydrochlorothiazide (25 mg) and amiloride (2-5 mg) in a combination tablet given twice daily gave better control of blood pressure in patients with mild to moderate essential hypertension than did equivalent dosages of timolol alone or of hydrochlorothiazide and amiloride. 4. Clinical and laboratory side effects were minimal.

在一项针对54例轻度至中度原发性高血压患者的双盲对照研究中，对单独使用噻吗洛尔以及噻吗洛尔与固定剂量的氢氯噻嗪和阿米洛利联合使用的效果进行了研究。2. 经过4周的安慰剂期后，患者被随机分配进入单独接受噻吗洛尔治疗的组（A组）、接受氢氯噻嗪+阿米洛利治疗的组（B组）或接受噻吗洛尔+氢氯噻嗪+阿米洛利治疗的组（C组）。每种治疗持续6周。3. 对于轻度至中度原发性高血压患者，每日服用两次的复方片剂中使用噻吗洛尔（10毫克）、氢氯噻嗪（25毫克）和阿米洛利（2 - 5毫克）比单独使用等量的噻吗洛尔或氢氯噻嗪与阿米洛利能更好地控制血压。4. 临床和实验室副作用极小。