Seccareccia F, Menotti A, Fazzini P F, Prati P L, Rovelli F, Antoniucci D, Menghini F
Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Rome, Italy.
Int J Cardiol. 1994 Jun 1;45(1):35-43. doi: 10.1016/0167-5273(94)90052-3.
An epidemiological study was conducted on 5163 men aged 40-59 years, made by occupational samples, from Florence and Rome to identify, by a three-stage procedure, subjects with asymptomatic silent ischemic heart disease (SIHD). This report describes some coronary risk factors. Men who are free from heart disease were compared with: (1) those having a low probability of SIHD (ECG signs only; n = 439); (2) those having a high probability of SIHD (ECG signs plus echographic signs, or positive markers of deficient perfusion, or altered radionuclide ventriculography; n = 104); (3) those having a definite SIHD (signs of the first two groups plus evidence from coronary angiography; n = 25). A clearcut increasing trend in the levels of major coronary risk factors, and in the multivariate estimated coronary risk for major events was found. The difference was not significant between highly probabile and definite cases of SIHD, due to the small numbers involved. Three multiple logistic models, with the three probability levels of silent ischemia as end-points, showed that four of 10 tested factors were associated with the presence of SIHD: age, systolic blood pressure, cigarette smoking and non-HDL serum cholesterol.
对来自佛罗伦萨和罗马的5163名40至59岁的男性进行了一项流行病学研究，这些男性通过职业抽样选取。研究采用三阶段程序来识别无症状性隐匿性缺血性心脏病（SIHD）患者。本报告描述了一些冠状动脉危险因素。将无心脏病的男性与以下几组进行比较：（1）SIHD可能性低的男性（仅有心电图迹象；n = 439）；（2）SIHD可能性高的男性（心电图迹象加超声心动图迹象，或灌注不足的阳性标志物，或放射性核素心室造影异常；n = 104）；（3）确诊为SIHD的男性（前两组的迹象加冠状动脉造影的证据；n = 25）。研究发现，主要冠状动脉危险因素水平以及主要事件的多变量估计冠状动脉风险呈明显上升趋势。由于涉及的病例数较少，SIHD高度可能病例与确诊病例之间的差异不显著。以隐匿性缺血的三个概率水平为终点的三个多元逻辑模型表明，所测试的10个因素中有4个与SIHD的存在相关：年龄、收缩压、吸烟和非高密度脂蛋白血清胆固醇。
