Niiyama Y, Fujiwara R, Satoh N, Hishikawa Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Int J Psychophysiol. 1994 Jul;17(2):165-74. doi: 10.1016/0167-8760(94)90032-9.
Information processing in the brain during sleep was studied by analyzing the evoked cortical response to auditory stimulations presented in the odd-ball paradigm. Eight subjects were examined in different sleep stages. The subjects could provide the correct behavioral response to the auditory stimulation by pressing a key button in the light part of stage 1 of NREM sleep, just succeeding to the waking state, but none of the subjects could give the correct behavioral response in the other sleep stages. In the deep part of stage 1 of NREM sleep and REM sleep, a cortical potential corresponding to P300, the endogenous component of the event-related potential (ERP) recorded in the waking state, was recorded in 6 of the 8 subjects in spite of the absence of the behavioral response. In stages 2, 3 and 4 of NREM sleep, emergence of this endogenous component of ERP could not be confirmed. The present findings provide electrophysiological evidence indicating that selective information processing corresponding to sensory discrimination of auditory stimuli is actively performed in stage 1 of NREM sleep and REM sleep.
通过分析在奇偶数范式中呈现的听觉刺激诱发的皮层反应，研究了睡眠期间大脑中的信息处理过程。对8名受试者在不同睡眠阶段进行了检查。受试者在非快速眼动睡眠（NREM）第1阶段的浅睡眠期，紧接清醒状态之后，能够通过按下按键对听觉刺激做出正确的行为反应，但在其他睡眠阶段，没有受试者能够做出正确的行为反应。在NREM第1阶段的深睡眠期和快速眼动睡眠期，尽管没有行为反应，但在8名受试者中的6名记录到了与P300相对应的皮层电位，P300是清醒状态下记录的事件相关电位（ERP）的内源性成分。在NREM睡眠的第2、3和4阶段，未证实ERP的这种内源性成分的出现。目前的研究结果提供了电生理证据，表明在NREM睡眠第1阶段和快速眼动睡眠期，与听觉刺激的感觉辨别相对应的选择性信息处理在积极进行。
