Burk R D, Hwang L Y, Ho G Y, Shafritz D A, Beasley R P
Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461.
J Infect Dis. 1994 Dec;170(6):1418-23. doi: 10.1093/infdis/170.6.1418.
To evaluate the role of maternal hepatitis B virus (HBV) DNA levels in perinatal infection, two nested case-control studies were done within a cohort of 773 hepatitis B surface antigen (HBsAg)-positive Taiwanese women and their infants. As serum HBV DNA levels increased from < 0.005 to > or = 1.4 ng/mL among the hepatitis B e antigen (HBeAg)-positive mothers, the odds ratio (OR) for having a persistently infected infant increased from 1.0 to 147.0 (P for trend < .001). Among HBeAg-negative mothers, the OR for having a persistently infected infant was 19.2 (95% confidence interval, 2.3-176.6) in mothers with high versus low levels of serum HBV DNA. A logistic regression analysis identified maternal HBV DNA to be a stronger independent predictor of persistent infection than HBeAg status. Thus, perinatal exposure to high levels of maternal HBV DNA is the most important determinant of infection outcome in the infant.
为评估母亲乙肝病毒（HBV）DNA水平在围产期感染中的作用，在一组773名乙肝表面抗原（HBsAg）阳性的台湾女性及其婴儿中开展了两项巢式病例对照研究。在乙肝e抗原（HBeAg）阳性母亲中，随着血清HBV DNA水平从<0.005 ng/mL升至≥1.4 ng/mL，婴儿持续感染的比值比（OR）从1.0增至147.0（趋势P<0.001）。在HBeAg阴性母亲中，血清HBV DNA水平高的母亲与水平低的母亲相比，婴儿持续感染的OR为19.2（95%置信区间，2.3 - 176.6）。逻辑回归分析表明，与HBeAg状态相比，母亲HBV DNA是持续性感染更强的独立预测因素。因此，围产期暴露于高水平母亲HBV DNA是婴儿感染结局的最重要决定因素。
