Buchheit J, Marshall G S, Rabalais G P, Dobbins G J
Division of neonatology, University of Louisville School of Medicine, KY 40202.
J Ky Med Assoc. 1994 Oct;92(10):411-5.
Using a passive surveillance system, 15 cases of symptomatic congenital cytomegalovirus (CMV) infection were identified in the Louisville area over approximately 3 years. When compared to mothers delivering healthy infants in Jefferson County, mothers of infants with congenital CMV were younger, more often nonwhite, and from lower socioeconomic status. Affected infants had a lower mean gestational age and birth weight, and most demonstrated classic features of congenital CMV infection such as jaundice, petechiae, hepatosplenomegaly, intrauterine growth retardation, and microcephaly. The overall infant mortality rate was 33%. Maternal and infant characteristics were similar to those of 167 cases in a national database and 106 cases reported from Birmingham, Alabama. The estimated minimal incidence of symptomatic congenital CMV disease in this area was 1.16/10,000 live births for white and 6.06/10,000 for nonwhites, establishing this as a significant public health problem in this part of Kentucky.
通过一个被动监测系统，在大约3年的时间里，路易斯维尔地区共确诊了15例有症状的先天性巨细胞病毒（CMV）感染病例。与杰斐逊县分娩健康婴儿的母亲相比，先天性CMV感染婴儿的母亲更年轻，非白人比例更高，社会经济地位更低。受感染的婴儿平均胎龄和出生体重较低，大多数表现出先天性CMV感染的典型特征，如黄疸、瘀点、肝脾肿大、宫内生长迟缓以及小头畸形。婴儿的总体死亡率为33%。母婴特征与国家数据库中的167例病例以及阿拉巴马州伯明翰市报告的106例病例相似。该地区有症状的先天性CMV疾病的估计最低发病率为白人每10000例活产中有1.16例，非白人每10000例活产中有6.06例，这表明在肯塔基州的这一地区，这是一个重大的公共卫生问题。
