Buffington C A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210-1089.
J Nutr. 1994 Dec;124(12 Suppl):2643S-2651S. doi: 10.1093/jn/124.suppl_12.2643S.
Companion animal diets may be related to prevention, pathogenesis and/or treatment of diseases of the lower urinary tract. For example, urolithiasis can be either diet induced or nutrient sensitive. One of the most interesting developments in veterinary urolithiasis research has been the recent change in the composition of stones recovered from cats. In 1984, 88% of stones analyzed by quantitative methods were > 70% struvite, whereas < 1% were calcium oxalate. In 1992, the percentage of struvite had dropped to 62, whereas the percentage of calcium oxalate had increased to 24. Another recent development in lower urinary tract disease of cats is the recognition that urolithiasis appears to be a minor cause of the signs of frequency, urgency and hematuria for which patients are presented. This suggests that diet may no longer be involved, or be involved in previously unrecognized ways, in many current cases of this disease. Some of these feline patients may have a disease similar to interstitial cystitis, a disease of humans that appears to be of neuroepithelial origin. Our laboratory has been studying this possibility recently, and many similarities between the two diseases have been found.
伴侣动物的饮食可能与下泌尿道疾病的预防、发病机制和/或治疗有关。例如，尿石症可能是饮食诱导的或对营养敏感的。兽医尿石症研究中最有趣的进展之一是最近从猫身上回收的结石成分发生了变化。1984年，通过定量方法分析的结石中88%的磷酸铵镁含量>70%，而草酸钙含量<1%。1992年，磷酸铵镁的百分比降至62%，而草酸钙的百分比增至24%。猫下泌尿道疾病的另一个最新进展是认识到尿石症似乎只是导致患者出现尿频、尿急和血尿症状的次要原因。这表明在当前许多这种疾病的病例中，饮食可能不再起作用，或者以以前未被认识的方式起作用。这些猫科动物患者中的一些可能患有一种与间质性膀胱炎类似的疾病，间质性膀胱炎是一种人类疾病，似乎起源于神经上皮。我们实验室最近一直在研究这种可能性，并且已经发现了这两种疾病之间的许多相似之处。
