Krajnc D, Wemlinger T A, Neff N H, Hadjiconstantinou M
Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210.
J Pharmacol Exp Ther. 1994 Dec;271(3):1299-305.
Brain neurotransmitter content and uptake activity were assessed in the brains of 7-day-old rats 15 min after exposure to hypoxia (8% O2-92% N2) for 3 hr. Glutamate, dopamine and choline uptake were decreased in the striatum, hippocampus and frontal cortex of the hypoxic animals. Moreover, the content of glutamate, dopamine and serotonin as well as the acidic metabolites of the two biogenic amines increased in the same tissues. Acetylcholine content was decreased in all three brain regions as well. Treating the animals with GM1 ganglioside before the insult prevented all neurochemical changes in the hypoxic neonatal brain. GM1 also prevented an hypoxia-induced decrease in phorbol ester binding. Finally, GM1 ganglioside reduced the mortality rate resulting from the hypoxic insult. Our results along with those in the literature suggest that GM1 might be useful for combating the pathology associated with perinatal hypoxia.
在7日龄大鼠暴露于低氧环境（8%氧气 - 92%氮气）3小时后15分钟，对其大脑中的神经递质含量和摄取活性进行评估。低氧动物的纹状体、海马体和额叶皮质中的谷氨酸、多巴胺和胆碱摄取减少。此外，相同组织中谷氨酸、多巴胺和血清素的含量以及这两种生物胺的酸性代谢产物增加。所有三个脑区的乙酰胆碱含量也降低。在损伤前用GM1神经节苷脂处理动物可防止低氧新生大脑中的所有神经化学变化。GM1还可防止低氧诱导的佛波酯结合减少。最后，GM1神经节苷脂降低了低氧损伤导致的死亡率。我们的结果以及文献中的结果表明，GM1可能有助于对抗围产期低氧相关的病理状况。
