Allbert J R, Johnson C, Roberts W E, Martin R W, Gookin K S, Morrison J C
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
J Reprod Med. 1994 Aug;39(8):614-8.
This study attempted to determine the best method of treatment for patients with recurrent preterm labor: administration of terbutaline via an automated, programmable, subcutaneous infusion pump or oral terbutaline. In this retrospective, controlled study, 32 patients diagnosed with recurrent preterm labor, as determined by persistent uterine contractions with cervical change, were treated with a programmable infusion pump adjusted to control uterine contraction frequency to < or = 4 contractions per hour. Patients in this group were matched for age, race, parity, gestational age and cervical dilation at diagnosis of recurrent preterm labor in subjects taking oral terbutaline. The patients receiving oral terbutaline were given an average of 6.5 mg every four to six hours to maintain uterine quiescence, while those in the pump group were given basal rates of terbutaline and in addition received four to six boluses per day (< 3 mg/d total dose) to achieve this outcome. Patients using the pump were more likely to reach term and less likely to fail tocolytic therapy than were those taking oral terbutaline. The terbutaline pump appeared to be more successful in prolonging pregnancies to term after the diagnosis of recurrent preterm labor than did oral terbutaline.
通过自动可编程皮下输注泵给予特布他林或口服特布他林。在这项回顾性对照研究中，32例经持续性子宫收缩伴宫颈变化确诊为复发性早产的患者，采用可编程输注泵进行治疗，将其调整以控制子宫收缩频率至每小时≤4次。该组患者在年龄、种族、产次、孕周以及复发性早产诊断时的宫颈扩张程度方面，与口服特布他林的受试者相匹配。接受口服特布他林的患者每4至6小时平均给予6.5毫克以维持子宫静息，而泵治疗组患者给予特布他林基础剂量，此外每天接受4至6次推注（总剂量<3毫克/天）以达到这一效果。与口服特布他林的患者相比，使用输注泵的患者更有可能足月分娩，且更不容易出现宫缩抑制治疗失败的情况。在复发性早产诊断后，特布他林泵在延长孕周至足月方面似乎比口服特布他林更成功。
