Hirano Y
Department of Pediatrics, Tokyo Women's Medical College.
Nihon Rinsho. 1994 Nov;52(11):2965-70.
Acute disseminated encephalomyelitis (ADEM) follows certain viral infection or vaccinations, which has a close etiological relationship to experimental autoimmune encephalomyelitis (EAE). Immunological examinations have not been sufficiently carried out on human ADEM except postmeasles encephalomyelitis. The most important pathogenic role in ADEM might be changes of immune regulatory mechanisms by virus infection. Therefore, it would be very useful to investigate cytokine, adhesion molecules and receptors on neural cells and endothelial cells in the central nervous system. Recently, the incidence of postvaccinated encephalomyelitis has reduced. Neurologic complications of immunization have been still reported, however, there is no scientific method to prove that the association is causal or coincidental in an individual case.
急性播散性脑脊髓炎（ADEM）继发于某些病毒感染或疫苗接种后，与实验性自身免疫性脑脊髓炎（EAE）存在密切的病因学关系。除麻疹后脑脊髓炎外，尚未对人类ADEM进行充分的免疫学检查。病毒感染引起的免疫调节机制变化可能在ADEM中起最重要的致病作用。因此，研究中枢神经系统神经细胞和内皮细胞中的细胞因子、黏附分子及受体将非常有用。近来，接种疫苗后脑脊髓炎的发病率有所降低。然而，免疫接种的神经系统并发症仍有报道，在个别病例中，尚无科学方法证明这种关联是因果关系还是巧合。
