Cossart P, Kocks C
Unité des Interactions Bactéries-Cellules, CNRS URA, Institut Pasteur, Paris, France.
Mol Microbiol. 1994 Aug;13(3):395-402. doi: 10.1111/j.1365-2958.1994.tb00434.x.
The Gram-positive bacterium Listeria monocytogenes is a facultative intracellular parasite that invades and multiplies within diverse eukaryotic cell types. An essential pathogenicity determinant is its ability to move in the host cell cytoplasm and to spread within tissues by directly passing from one cell to another. The propulsive force for intracellular movement is thought to be generated by continuous actin assembly at the rear end of the bacterium. Moving bacteria that reach the plasma membrane induce the formation of long membranous protrusions that are internalized by neighbouring cells, thus mediating the spread of infection. The unrelated pathogens Shigella and Rickettsia use a similar process of actin-based motility to disseminate in infected tissues. This review focuses on the bacterial and cellular factors involved in the actin-based motility of L. monocytogenes.
革兰氏阳性菌单核细胞增生李斯特菌是一种兼性细胞内寄生虫，可在多种真核细胞类型中侵入并繁殖。一个关键的致病性决定因素是它在宿主细胞质中移动并通过直接从一个细胞传递到另一个细胞在组织内传播的能力。细胞内移动的推进力被认为是由细菌后端连续的肌动蛋白组装产生的。到达质膜的移动细菌会诱导形成长的膜状突起，这些突起会被邻近细胞内化，从而介导感染的传播。不相关的病原体志贺氏菌和立克次氏体利用类似的基于肌动蛋白的运动过程在受感染组织中传播。这篇综述聚焦于参与单核细胞增生李斯特菌基于肌动蛋白运动的细菌和细胞因子。
