Lohiya N K, Goyal R B, Jayaprakash D, Ansari A S, Sharma S
Department of Zoology, University of Rajasthan, Jaipur, India.
Planta Med. 1994 Oct;60(5):400-4. doi: 10.1055/s-2006-959518.
The influence of the crude aqueous extract of Carica papaya L. (Caricaceae) seeds has been studied on semen profile, fertility, body and organ weight response, and toxicology in male albino rats. The extract was administered at the dose regimens of 10 and 50 mg/animal/day orally for 30, 60, and 90 days and 0.1 and 1.0 mg/animal/day intramuscularly for 15 and 30 days. Cauda epididymal sperm motility and count was reduced significantly at low and high dose regimens both in the oral as well as the intramuscular groups. The reduced sperm motility was associated with morphological defects. Testicular sperm counts were also reduced in all the treatment groups except the low dose intramuscular group. Fertility tests showed dose- and duration-dependent reduction and zero fertility was observed at high dose regimens of the oral and intramuscular groups following 60 and 30 days of treatment, respectively. Testicular weight was reduced in all the treatment groups, whereas accessory sex organs showed a variable response. Body weight and toxicological observations did not show any untoward response. Fertility and all other associated changes returned to normal within 45 and 30 days of treatment cessation in the oral and intramuscular groups, respectively. The data revealed that reversible sterility could be induced in male rats by papaya seeds aqueous extract treatment without adverse effects on libido and toxicological profile.
已研究了番木瓜（番木瓜科）种子的粗水提取物对雄性白化大鼠精液参数、生育能力、体重和器官重量反应以及毒理学的影响。提取物以10和50毫克/动物/天的剂量口服给药30、60和90天，以及以0.1和1.0毫克/动物/天的剂量肌肉注射给药15和30天。口服组和肌肉注射组在低剂量和高剂量方案下，附睾尾部精子活力和计数均显著降低。精子活力降低与形态缺陷有关。除低剂量肌肉注射组外，所有治疗组的睾丸精子计数也均降低。生育力测试显示，口服组和肌肉注射组在分别治疗60天和30天后，高剂量方案下生育力呈剂量和时间依赖性降低，且观察到零生育力。所有治疗组的睾丸重量均降低，而附属生殖器官则表现出不同的反应。体重和毒理学观察未显示任何不良反应。口服组和肌肉注射组在停止治疗后45天和30天内，生育力和所有其他相关变化分别恢复正常。数据显示，番木瓜种子水提取物处理可诱导雄性大鼠可逆性不育，且对性欲和毒理学特征无不良影响。
