Lohiya N K, Goyal R B
Department of Zoology, University of Rajasthan, Jaipur, India.
Indian J Exp Biol. 1992 Nov;30(11):1051-5.
Crude chloroform extract of C. papaya seeds (5 mg/animal/day, po, for 20, 40 and 60 days) was investigated for contraceptive efficacy and related side effects in male albino rats. The crude extract reduced fertility to zero per cent by 40 to 60 days of treatment. Suppression of cauda epididymal sperm motility was the most pronounced effect of the drug administration. Scanning electron microscopic observations revealed treatment induced abnormalities in sperms. Cauda epididymal and testicular sperm counts decreased following treatment. Clinical parameters did not show any alterations. Results suggest that the contraceptive effects of chloroform extract of papaya seeds are mainly post-testicular in nature without influencing toxicological profile and libido of the animals.
对雄性白化大鼠研究了番木瓜种子的粗氯仿提取物（5毫克/动物/天，经口给药，持续20、40和60天）的避孕效果及相关副作用。经40至60天的治疗，粗提取物使生育力降至零。给药后最显著的作用是抑制附睾尾部精子活力。扫描电子显微镜观察显示治疗导致精子出现异常。治疗后附睾尾部和睾丸的精子计数减少。临床参数未显示任何改变。结果表明，番木瓜种子氯仿提取物的避孕作用主要是睾丸后性的，且不影响动物的毒理学特征和性欲。
