Hiraishi K, Narabayashi I, Fujita O, Yamamoto K, Sagami A, Hisada Y, Saika Y, Adachi I, Hasegawa H
Department of Radiology, Osaka Medical College, Japan.
Radiology. 1995 Jan;194(1):119-23. doi: 10.1148/radiology.194.1.7997537.
To evaluate the use of blueberry juice as an oral contrast agent in magnetic resonance (MR) imaging.
MR imaging of phantoms of blueberry juice and of manganese chloride solutions with different manganese concentrations were conducted. Patient trials were conducted to evaluate manganese blood levels and signal intensity changes on MR images of the abdomen. T1- and T2-weighted conventional spin-echo MR imaging was performed at various field strengths. Six radiologists graded image contrast; signal intensities were calculated.
T1 and T2 relaxation curves for blueberry juice and manganese chloride showed similar signal intensity profiles as a function of manganese concentration. Blood concentrations of manganese were unchanged before and after an oral dose of blueberry juice that contained 18 mg of manganese. The results of patient studies indicated that the optimal oral dose of manganese in blueberry juice was 3-4 mg/dL. T1 and T2 shortening were apparent at field strengths of 0.2-1.5 T.
At appropriate concentrations, blueberry juice has the potential to be an effective oral contrast agent for MR imaging.
评估蓝莓汁作为磁共振成像（MR）口服造影剂的应用。
对不同锰浓度的蓝莓汁和氯化锰溶液模型进行磁共振成像。进行患者试验以评估锰的血药浓度以及腹部磁共振图像上的信号强度变化。在不同场强下进行T1加权和T2加权常规自旋回波磁共振成像。6名放射科医生对图像对比度进行评分；计算信号强度。
蓝莓汁和氯化锰的T1和T2弛豫曲线显示，作为锰浓度的函数，信号强度分布相似。口服含18 mg锰的蓝莓汁前后，锰的血药浓度未发生变化。患者研究结果表明，蓝莓汁中锰的最佳口服剂量为3 - 4 mg/dL。在0.2 - 1.5 T的场强下，T1和T2缩短明显。
在适当浓度下，蓝莓汁有潜力成为一种有效的磁共振成像口服造影剂。
