Espinosa María G, Sosa Modesto, De León-Rodríguez Luis M, Córdova Teodoro, Bernal-Alvarado Jesus, Avila-Rodríguez Mario, Reyes-Aguilera Jose A, Ortíz Juan J, Barrios Fernando A
Facultad de Física e Inteligencia Artificial, Universidad Veracruzana, 91090 Xalapa, Ver., México.
Magn Reson Imaging. 2006 Feb;24(2):195-200. doi: 10.1016/j.mri.2005.10.026. Epub 2005 Dec 27.
In this study, seven fruits have been tested on their magnetic properties, paramagnetic metal content and contrast enhancement in magnetic resonance imaging (MRI) of phantom and in vivo. Magnetic susceptibility was determined for the fruit pulps, as well as the contents of paramagnetic metals; iron, manganese and copper. The total content of these metals was 4.3, 8.6, 11.1, 10.9, 12.3, 8.3 and 29.3 mg/kg of fruit for plum, blueberry, apple (red), pineapple, beet, grape, blackberry, respectively, and with magnetic susceptibility of -2.29+/-0.07, -2.43+/-0.07, -2.13+/-0.07, -1.84+/-0.02, -1.75+/-0.01, -1.78+/-0.06, -2.18+/-0.07 SI, respectively. T(1)- and T(2)-weighted MR images were performed for the seven fruits and water (chi= -9.98 x 10(-3) SI) and in one subject. While there was no correlation between the magnetic susceptibility and contrast enhancement, there is a correlation with the total paramagnetic metal content determined with contrast enhancement in MRI. Thus, blackberry (Rubus spp.) contrast enhancement was the highest among the fruits in T(1)-weighted images. Furthermore, this fruit's contrast enhancement shows to be pH-dependent. These characteristics and the wide availability of the Rubus spp. suggest that it should be implemented as an oral contrast agent in images by MR to assess the function of the gastric section of the GI tract. Furthermore, it has the advantage of being a natural meal, so that it can be well tolerated by the patients and use as much as it is needed without side effects.
在本研究中，对七种水果的磁性、顺磁性金属含量以及在体模和活体磁共振成像（MRI）中的对比增强效果进行了测试。测定了果肉的磁化率以及顺磁性金属（铁、锰和铜）的含量。这些金属的总含量分别为：李子4.3毫克/千克、蓝莓8.6毫克/千克、红苹果11.1毫克/千克、菠萝10.9毫克/千克、甜菜12.3毫克/千克、葡萄8.3毫克/千克、黑莓29.3毫克/千克，磁化率分别为-2.29±0.07、-2.43±0.07、-2.13±0.07、-1.84±0.02、-1.75±0.01、-1.78±0.06、-2.18±0.07 SI。对这七种水果以及水（χ=-9.98×10⁻³ SI）进行了T1加权和T2加权MR图像扫描，并在一名受试者身上进行了测试。虽然磁化率与对比增强之间没有相关性，但与MRI中通过对比增强测定的总顺磁性金属含量存在相关性。因此，在T1加权图像中，黑莓（悬钩子属）的对比增强效果在所有水果中最高。此外，这种水果的对比增强效果显示出与pH值有关。悬钩子属植物的这些特性以及广泛可得性表明，它应作为一种口服对比剂用于MR成像，以评估胃肠道胃部的功能。此外，它具有天然食物的优势，患者耐受性良好，可以按需大量使用且无副作用。
