Capron L
Rev Neurol (Paris). 1993;149(12):751-4.
Atherosclerotic plaques harbour 3 main cell types: arterial smooth muscle cells, monocyte-macrophages and T-lymphocytes. Together with other morphological characteristics, this feature concurs to the view that plaques are foci of chronic inflammation. The presence of T-cells suggests that immune mechanisms are involved in the development of atherosclerosis. Clinical studies have found correlations between the presence or progression of carotid plaques and the serum concentration of antibodies against oxidized low-density lipoproteins and against heat shock protein HSP-65. Along with other observations, these correlations, if confirmed and extended, may open new avenues to understand the triggering mechanisms of atherosclerosis. However, the available evidence is still insufficient to establish that an autoimmune involvement is a cause rather than a consequence of atherosclerosis.
动脉平滑肌细胞、单核细胞 - 巨噬细胞和T淋巴细胞。连同其他形态学特征，这一特点支持了斑块是慢性炎症病灶的观点。T细胞的存在表明免疫机制参与了动脉粥样硬化的发展。临床研究发现颈动脉斑块的存在或进展与抗氧化型低密度脂蛋白抗体和抗热休克蛋白HSP - 65的血清浓度之间存在相关性。连同其他观察结果，如果这些相关性得到证实和扩展，可能会为理解动脉粥样硬化的触发机制开辟新途径。然而，现有证据仍不足以确定自身免疫参与是动脉粥样硬化的原因而非结果。
