Coelho P M, de Mello R T, Gerken S E
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Rev Inst Med Trop Sao Paulo. 1993 Nov-Dec;35(6):557-61. doi: 10.1590/s0036-46651993000600013.
Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preventing their migration from the skin to the lungs. Worm recovery performed in the lungs (96 hours after treatment) showed recovery means of 0.6 worms/mouse in the treated group and 53.8 in the control group (untreated). The perfusion of the portal system carried out at 35 days after treatment clearly showed the elimination of all the parasites in the treated group, whereas a recovery mean of 144.7 worms/mouse was detected in the control group (untreated). These findings confirm the efficacy of oxamniquine at the skin phase of infection, and also show similarity with the immunization method that uses irradiated cercariae. The practical application of these findings in the medical clinic is discussed too.
感染约400只尾蚴的小鼠在感染后24小时接受奥沙尼喹（400mg/kg）治疗。在治疗后4、24、48和72小时以及35天对童虫的回收情况显示了该药物对寄生虫的活性，从而实际上阻止了它们从皮肤向肺部的迁移。在肺部进行的虫体回收（治疗后96小时）显示，治疗组每只小鼠的回收平均数为0.6条虫，而对照组（未治疗）为53.8条。治疗后35天对门静脉系统进行灌注，结果清楚地显示治疗组所有寄生虫均被清除，而对照组（未治疗）每只小鼠的回收平均数为144.7条虫。这些发现证实了奥沙尼喹在感染皮肤期的疗效，并且还显示出与使用辐照尾蚴的免疫方法相似。文中还讨论了这些发现在医学临床中的实际应用。
