Sabbaga E, Tedesco-Marchesi L M, Lacaz C da S, Cucé L C, Salebian A, Heins-Vaccari E M, Sotto M N, Valente N Y, Porto E, Levy Neto M
Unidade de Transplante Renal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brasil.
Rev Inst Med Trop Sao Paulo. 1994 Mar-Apr;36(2):175-83.
We report three cases of subcutaneous phaeohyphomycosis due to Exophiala jeanselmei (Langeron) McGinnis et Padhye 1977, in kidney transplant patients. Exophiala jeanselmei is a dematious fungus having also ability to rarely procedure eumycetoma (black grains). According to KWON-CHUNG & BENNETT (1992) such fungus is antigenically very heterogeneous, since so far three serotypes have been identified; each serotype including subgroups. Subcutaneous phaeohyphomycosis is becoming more and more frequent in kidney transplant patients submitted to an immunosuppressive treatment. As Exophiala jeanselmei has already been isolated from the environment it becomes difficult to explain the pathogenicity of these cases by a reactivation of quiescent processes. The authors suggest an occasional fungistatic action of cyclosporine A upon Exophiala jeanselmei.
我们报告了3例肾移植患者因1977年麦金尼斯和帕德海命名的耶氏外瓶霉（兰热龙）引起的皮下暗色丝孢霉病。耶氏外瓶霉是一种暗色真菌，也很少能引起真菌性足菌肿（黑色颗粒）。根据权钟和贝内特（1992年）的研究，这种真菌在抗原性上非常异质，因为到目前为止已鉴定出三种血清型；每种血清型包括多个亚组。在接受免疫抑制治疗的肾移植患者中，皮下暗色丝孢霉病越来越常见。由于耶氏外瓶霉已从环境中分离出来，因此很难通过静止过程的重新激活来解释这些病例的致病性。作者认为环孢素A对耶氏外瓶霉偶尔有抑菌作用。
