[奥斯陆艾滋病毒队列研究中的艾滋病风险。同性恋男性、静脉吸毒者和异性恋者之间的比较]

[Risk of AIDS in the Oslo HIV-cohort study. A comparison between homosexual men, intravenous addicts and heterosexual persons].

作者信息

Eskild A, Heger B, Bruun J N, Frøland S S, Iversen B, Løvik M, Samdal H H, Magnus P, Bakketeig L S

机构信息

Avdeling for samfunnsmedisin Statens Institutt for Folkehelse, Oslo.

出版信息

Tidsskr Nor Laegeforen. 1994 Oct 10;114(24):2831-4.

PMID:7998028

Abstract

In order to study differences in risk of the development of AIDS in different groups of HIV infected subjects, 151 homosexual men, 110 intravenous drug users (IVDUs) and 36 heterosexually infected persons without major signs of HIV infection at entry to the study were enrolled in a cohort study. The mean follow-up time was 35 months. At the end of follow-up 40 subjects (13%) were diagnosed as having AIDS. This represented 20% (31/151) of the homosexual men, 7% (8/110) of the IVDUs and 3% (1/36) of the heterosexual subjects. The probability of being AIDS-free 36 months after entering the study was 0.88 (0.84-0.92, 95% CI) for the total study population, 0.83 (0.77-0.90) for the homosexual men, 0.92 (0.86-0.99) for IVDUs and 0.93 (0.91-1.0) for heterosexual subjects (p < 0.05, log rank test). In a Cox regression analysis, adjusting for CD4+ cell count at study entry, the relative risk of AIDS progression was 2.4 (1.1-5.2) for homosexual men and 0.3 (0.04-2.4) for heterosexual subjects, compared with IVDUs. The results demonstrate a higher risk of AIDS for homosexual men during the follow-up period.

摘要

为研究不同组HIV感染者患艾滋病风险的差异，151名男同性恋者、110名静脉注射吸毒者（IVDUs）和36名在研究开始时无HIV感染主要体征的异性感染者被纳入一项队列研究。平均随访时间为35个月。随访结束时，40名受试者（13%）被诊断为患有艾滋病。这分别占男同性恋者的20%（31/151）、静脉注射吸毒者的7%（8/110）和异性感染者的3%（1/36）。整个研究人群在进入研究36个月后未患艾滋病的概率为0.88（0.84 - 0.92，95%可信区间），男同性恋者为0.83（0.77 - 0.90），静脉注射吸毒者为0.92（0.86 - 0.99），异性感染者为0.93（0.91 - 1.0）（p < 0.05，对数秩检验）。在Cox回归分析中，在对研究开始时的CD4 + 细胞计数进行校正后，与静脉注射吸毒者相比，男同性恋者艾滋病进展的相对风险为2.4（1.1 - 5.2），异性感染者为0.3（0.04 - 2.4）。结果表明，在随访期间男同性恋者患艾滋病的风险更高。