弯叶离心泵中血小板损伤较少：与心脏直视手术中滚压泵的对比研究

Less platelet damage in the curved vane centrifugal pump: a comparative study with the roller pump in open heart surgery.

作者信息

Nishinaka T, Nishida H, Endo M, Koyanagi H

机构信息

Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.

出版信息

Artif Organs. 1994 Sep;18(9):687-90. doi: 10.1111/j.1525-1594.1994.tb03400.x.

DOI:10.1111/j.1525-1594.1994.tb03400.x

PMID:7998887

Abstract

The centrifugal pump with the curved vane (Lifestream Centrifugal Pump [LCP]) was applied to cardiopulmonary bypass (CPB) in 10 patients who underwent elective coronary artery bypass grafting. Serum hemoglobin levels, platelet counts, and serum beta-thromboglogulin (beta-TG) levels were measured during CPB. The results were compared with those for a comparative roller pump (RP) group (n = 10). There was no difference in CPB time between LCP (112 +/- 22 min) and RP (121 +/- 22 min) groups. Serum beta-TG levels (ng/ml) were lower in the LCP group than in the RP group (34 +/- 9 vs. 101 +/- 80, 5 min; 81 +/- 33 vs. 236 +/- 112, 30 min; 120 +/- 53 vs. 314 +/- 100, 60 min after initiation of CPB; p < 0.05). There were no significant differences in hemolysis and platelet depletion. The LCP showed excellent hemodynamic performance with less blood trauma in clinical application to open heart surgery.

摘要

将带有弯曲叶片的离心泵（生命流离心泵[LCP]）应用于10例行择期冠状动脉旁路移植术患者的体外循环（CPB）中。在CPB期间测量血清血红蛋白水平、血小板计数和血清β-血小板球蛋白（β-TG）水平。将结果与对照滚压泵（RP）组（n = 10）的结果进行比较。LCP组（112±22分钟）和RP组（121±22分钟）的CPB时间无差异。LCP组的血清β-TG水平（ng/ml）低于RP组（CPB开始后5分钟时为34±9 vs. 101±80；30分钟时为81±33 vs. 236±112；60分钟时为120±53 vs. 314±100；p < 0.05）。溶血和血小板消耗方面无显著差异。在心脏直视手术的临床应用中，LCP显示出优异的血流动力学性能且血液损伤较小。